Author/Authors :
Khalili, Davood Prevention of Metabolic Disorders Research Center - Research Institute for Endocrine Sciences - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Azizi, Fereidoun Endocrine Research Center - Research Institute for Endocrine Sciences - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Asgari, Samaneh Prevention of Metabolic Disorders Research Center - Research Institute for Endocrine Sciences - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Zadeh-Vakili, Azita Cellular and Molecular Endocrine Research Center - Research Institute for Endocrine Sciences - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Momenan, Amir Abbas Prevention of Metabolic Disorders Research Center - Research Institute for Endocrine Sciences - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Ghanbarian, Arash Prevention of Metabolic Disorders Research Center - Research Institute for Endocrine Sciences - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Eskandari, Fatemeh Prevention of Metabolic Disorders Research Center - Research Institute for Endocrine Sciences - Shahid Beheshti University of Medical Sciences, Tehran , Sheikholeslami, Farhad Prevention of Metabolic Disorders Research Center - Research Institute for Endocrine Sciences - Shahid Beheshti University of Medical Sciences, Tehran , Hadaegh, Farzad Prevention of Metabolic Disorders Research Center - Research Institute for Endocrine Sciences - Shahid Beheshti University of Medical Sciences, Tehran
Abstract :
Context: The Tehran lipid and glucose study (TLGS) is one of the oldest population-based longitudinal cohort studies, providing
knowledge about the incidence and risk factors of some non-communicable diseases (NCDs) inWest Asia which hitherto was relatively
scarce. We reviewed the methods and results related to the outcome measurements of this study.
Evidence Acquisition: We reviewed all the TLGS papers which reported the incidence of NCDs.
Results: The TLGS was initiated in 1999 - 2001 on a population in district no. 13 of Tehran with the same age distribution of the overall
Tehran population and with a middle socioeconomic status. Totally, 15005 individuals, aged 3 years, participated in the first
examination; reexaminations were conducted in a triennial manner and 3550 individuals were added in the second examination.
All participants were also followed up annually and asked about any medical event leading to hospitalization or death. A part of
participants was assigned to an educational program for lifestyle modification. High incidence of cardiovascular disease (CVD),
premature CVD, diabetes and hypertension (around 19, 6, 10 and 31 in men and 11, 5, 11 and 29 in women per 1000 person-year, respectively)
besides the high incidence of pre-diabetes and pre-hypertension (around 46 and 76 in men and 37 and 49 in women per 1000
person-year, respectively) showed a worrying situation. Fortunately, the results of the community interventions were promising
with around 20% reduction in the risk of metabolic syndrome up to six years.
Conclusions: These precise detections of different outcomes in the TLGS provided valuable evidences for prediction and prevention
of NCDs in Iran with some novelties in the middle-income countries in the world. The Tehran thyroid study (TTS) and the Tehran cardiometabolic
genetic study (TCGS), conducted in the framework of the TLGS, areamongfew studies aiming to determine the natural
course of thyroid function and to identify patterns of genetic polymorphisms related to cardiometabolic outcomes, respectively.
