Title of article :
Association Study between Functional Polymorphisms of MMP9 Gene Promoter and Multiple Sclerosis Susceptibility in an Iranian Population
Author/Authors :
SABBAGH ، Sima Isfahan Neurosciences Research Center, Al-Zahra Research Institute - Isfahan University of Medical Sciences , NADEALI ، Zakiye Medical Genetics Laboratory - Isfahan Neurosciences Research Center, Al-Zahra Research Institute, Al-Zahra University Hospital - Isfahan University of Medical Sciences , DEHGHANI ، Leila Department of Tissue Engineering and Regenerative Medicine - School of Advanced Technologies in Medicine - Shahid Beheshti University of Medical Sciences , SHAYGANNEJAD ، Vahid Isfahan Neurosciences Research Center, Al-Zahra Research Institute - Isfahan University of Medical Sciences , REZVANI ، Majid Department of Neurosurgery - School of Medicine - Isfahan University of Medical Sciences , SABOORI ، Masih Department of Neurosurgery - School of Medicine - Isfahan University of Medical Sciences , GANJI ، Hamid Isfahan Neurosciences Research Center, Al-Zahra Research Institute - Isfahan University of Medical Sciences , TAHANI ، Soheil Isfahan Neurosciences Research Center, Al-Zahra Research Institute - Isfahan University of Medical Sciences , DEHGHANI ، Farzaneh Isfahan Neurosciences Research Center, Al-Zahra Research Institute - Isfahan University of Medical Sciences , HOSSEINZADEH ، Saman Isfahan Neurosciences Research Center, Al-Zahra Research Institute - Isfahan University of Medical Sciences , MARZBANI ، Elnaz Isfahan Neurosciences Research Center, Al-Zahra Research Institute - Isfahan University of Medical Sciences , SHAFIEI ، Peiman Isfahan Neurosciences Research Center, Al-Zahra Research Institute - Isfahan University of Medical Sciences
Abstract :
Background: Matrix metalloproteinase-9 (MMP-9) polymorphisms, C−1562 T and -90 (CA) n repeats, which influence transcriptional activity of this gene, are proposed to play a role in MS susceptibility and its development. In the present study, the possible association of MMP-9 polymorphisms in Iranian MS patients is studied. Methods: Association of MMP-9 mentioned gene polymorphisms with MS susceptibility was evaluated in unrelated Iranian subjects referred to Al-Zahra Hospital, Isfahan, Iran during 2014 to 2017. Results: -1562 T allele of MMP-9 was associated with increased MS risk. However, we found no overall significant effect of −90 (CA)n repeat on MS susceptibility. Conclusion: For as much as MMP-9 molecule is a potential target for MS therapy, to determine whether any of MMP-9 polymorphisms influence MS susceptibility in Iranian MS patients or not, concerning the significant influence of T allele on MS susceptibility and the non-significant association regarding CA repeats, further research is needed before proposing any definite conclusion.
Keywords :
Multiple sclerosis , MMP , 9 gene , Polymorphism , Association study
Journal title :
Iranian Journal of Public Health
Journal title :
Iranian Journal of Public Health
