Author/Authors :
naderi, majid Genetics of Non-Communicable Disease Research Center - Zahedan University of Medical Sciences , shahramian, iraj Pediatric Digestive and Hepatic Research Center - Zabol University of Medical Sciences , bazi, ali Faculty of Allied Medical Sciences - Zabol University of Medical Sciences , delaramnasab, mojtaba Faculty of Allied Medical Sciences - Zabol University of Medical Sciences , kalvandi, gholamreza Department of Pediatrics and Medicine - Faculty of Medicine - Ilam University of Medical Sciences
Abstract :
introduction:extrahepatic presentation in hepatitis is a relatively uncommon clinical condition. in particular, pancytopenia related to hepatitis is a rare phenomenon encountered in these patients. pancytopenia can be associated with a variety of hepatitis viruses; however, its association with hepatitis a virus (hav) is unusual. case presentation:in current case series, we reported 11 children who presented with three suppressed blood lineages, including white blood cells, platelets, reticulocytes, and hemoglobin with mean values of 2.4 x d7; 103/µl, 54.5 xd7; 103/µl, 1%, and 9.4 g/dl. of these 11 children, 5 were boys. the mean age was 6.5 years old. the patients presented with abdominal pain, hepatitis, and pallor. biochemical analysis showed liver function enzymes were increased in all patients. serologic studies for antibodies against viral components, including hepatitis b (hbv), hepatitis c (hcv), and hav, as well as cytomegalovirus (cmv) showed positive results for antihav igm. coombs tests were negative in all the patients. conclusions:clinicians should consider extrahepatic presentations of hepatitis infections, especially hav infection that may present with nonspecific clinical features. this can help health care providers to timely and correct diagnosis and treatment of this infection.
