Author/Authors :
Goodarzi, Parisa Brain and Spinal Cord Injury Research Center - Neuroscience Institute - Tehran University of Medical Sciences, Tehran , Alavi- Moghadam, Sepideh Cell Therapy and Regenerative Medicine Research Center - Endocrinology and Metabolism Molecular- Cellular Sciences Institute - Tehran University of Medical Sciences, Tehran , Tayanloo- Beik, Akram Cell Therapy and Regenerative Medicine Research Center - Endocrinology and Metabolism Molecular- Cellular Sciences Institute - Tehran University of Medical Sciences, Tehran , Foroughi Heravani, Najmeh Cell Therapy and Regenerative Medicine Research Center - Endocrinology and Metabolism Molecular- Cellular Sciences Institute - Tehran University of Medical Sciences, Tehran , Hadavandkhani, Mahdieh Cell Therapy and Regenerative Medicine Research Center - Endocrinology and Metabolism Molecular- Cellular Sciences Institute - Tehran University of Medical Sciences, Tehran , Arjmand, Babak Cell Therapy and Regenerative Medicine Research Center - Endocrinology and Metabolism Molecular- Cellular Sciences Institute - Tehran University of Medical Sciences, Tehran , Payab, Moloud Obesity and Eating Habits Research Center - Endocrinology and Metabolism Molecular-Cellular Sciences Institute - Tehran University of Medical Sciences, Tehran , Larijani, Bagher Endocrinology and Metabolism Research Center - Endocrinology and Metabolism Clinical Sciences Institute - Tehran University of Medical sciences, Tehran , Rahim, Fakher Health Research Institute - Thalassemia and Hemoglobinopathies Research Center - Ahvaz Jundishapur University of Medical Sciences, Ahvaz , Gilany, Kambiz Integrative Oncology Department - Breast Cancer Research Center - Motamed Cancer Institute - ACECR, Tehran , Bana, Nikoo Metabolomics and Genomics Research Center - Endocrinology and Metabolism Molecular- Cellular Sciences Institute - Tehran University of Medical Sciences, Tehran
Abstract :
Various mesenchymal stem cells as easily accessible and multipotent cells can share different essential signaling pathways related to their stemness ability. Understanding the mechanism of stemness ability can be useful for controlling the stem cells for regenerative medicine targets. In this context, OMICs studies can analyze the mechanism of different stem cells properties or stemness ability via a broad range of current high-throughput techniques. This field is fundamentally directed toward the analysis of whole genome (genomics), mRNAs (transcriptomics), proteins (proteomics) and metabolites (metabolomics) in biological samples. According to several studies, metabolomics is more effective than other OMICs ّfor various systems biology concerns. Metabolomics can elucidate the biological mechanisms of various mesenchymal stem cells function by measuring their metabolites such as their secretome components. Analyzing the metabolic alteration of mesenchymal stem cells can be useful to promote their regenerative medicine application.
Keywords :
Mesenchymal stem cells , metabolic pathways , metabolomics , systems biology
