Author/Authors :
Sarhangi, Negar Personalized Medicine Research Center - Endocrinology and Metabolism Clinical Sciences Institute - Tehran University of Medical Sciences, Tehran , Mohammad Amoli, Mahsa Metabolic Disorders Research Center - Endocrinology and Metabolism Molecular-Cellular Sciences Institute - Tehran University of Medical Sciences, Tehran , Shahrabi-Farahani, Maryam Metabolic Disorders Research Center - Endocrinology and Metabolism Molecular-Cellular Sciences Institute - Tehran University of Medical Sciences, Tehran , Mohseni, Shahrzad Endocrinology and Metabolism Research Center - Endocrinology and Metabolism Clinical Sciences Institute - Tehran University of Medical Sciences, Tehran , Aminimoghaddam, Soheila Department of Obstetrics and Gynecology - Iran University of Medical Sciences, Tehran , Haghollahi, Fedyeh Department of Obstetrics and Gynecology - Iran University of Medical Sciences, Tehran , Hossein Rashidi, Batool Vali-e-Asr Reproductive Health Research Center - Tehran University of Medical Sciences, Tehran , Qorbani, Mostafa Department of Community Medicine - School of Medicine - Alborz University of Medical Sciences, Karaj
Abstract :
Endometriosis is a debilitating disorder, defined as the presence of endometrial gland and stroma outside of the uterus. It may affect angiogenesis and vascular endothelial growth factor (VEGF) is one of the angiogenic factors that plays an important role in both physiological and pathological angiogenesis. The present study aimed to evaluate the association of VEGF -2549 insertion/deletion (I/D) polymorphism with endometriosis. This case-control study enrolled 244 (100 cases and 144 controls) women who were admitted for laparoscopy or laparotomy for gynecological procedures. Genomic DNA was separated from peripheral blood leukocytes and polymerase chain reaction amplification was performed for genotyping of the VEGF gene Insertion/Deletion (I/D) polymorphism. The frequency of the II, ID, and DD genotype was 14%, 52% and 34% in patients versus 18.8%, 47.8% and 34% in controls. The results did not provide any evidence supporting the endometriosis risk related to the VEGF polymorphism in Iranian women population.
Keywords :
Endometriosis , vascular endothelial growth factor , VEGF , -2549 I/D , polymorphism
