Author/Authors :
Hassanipour, Soheil Gastrointestinal and Liver Diseases Research Center - Guilan University of Medical Sciences, Rasht, Iran , Fathalipour, Mohammad Department of Pharmacology and Toxicology - Faculty of Pharmacy - Hormozgan University of Medical Sciences, Bandar Abbas, Iran , Delam, Hamed Student Research Committee - Larestan University of Medical Sciences, Larestan, Iran , Ghorbani, Mohammad Department of Public Health - School of Health - Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran , Abdzadeh, Elham GI Cancer Screening and Prevention Research Center - Guilan University of Medical Sciences, Rasht, Iran , Arab-Zozani, Morteza Iranian Center of Excellence in Health Management - School of Management and Medical Informatics - Tabriz University of Medical Sciences, Tabriz, Iran , Riahi, Shirin Non-communicable Diseases Research Center - Alborz University of Medical Sciences, Karaj, Iran , Salehiniya, Hamid Social Determinants of Health Research Center - Birjand University of Medical Sciences, Birjand, Iran
Abstract :
Background: Childhood cancer (ChC) is very rare and occurs between birth and 14 years of age. There are
several reports about ChC incidence from various regions of Iran, but with conflicting results. The present study
aimed to do a systematic review to estimate the accurate incidence rate of ChC among Iranian people.
Materials and Methods: This systematic review was performed based on the Preferred Reporting Items for
Systematic Reviews and Meta-analyses (PRISMA) checklist in 2018. A literature search was conducted using
international databases (Medline/PubMed, Scopus, ISI/Web of Knowledge, and Google Scholar) for English
papers, and national databases (Scientific Information Database, MagIran, IranMedex, and IranDoc) for Persian
papers which estimated the incidence rate of ChC in any geographical location in Iran. The incidence rate of
ChC was calculated using random-effect model.
Results: Out of 157 papers in the primary searches, 12 studies were included by advanced screening and
refinement. The crude incidence rate (CIR) of ChC in 0-14 years was 16.8 per 100,000 (95% CI: 9.04-24.56) for
boys and 16.56 per 100,000 (95% CI: 10.51-22.62) for girls.
Conclusion: The incidence of ChC in Iran is higher compared to other parts of the world. Considering this
issue, holding some interventional programs on tackling potential risk factors, including air pollution, in
different regions of Iran is suggested.
