Title of article
Calcium Antagonistic Activity of Biophytum Petersianum on Vascular Smooth Muscles of Wistar Rat
Author/Authors
TITRIKOU, SIMÉNOU Faculté des Sciences - Centre de Recherche et de Formation sur les Plantes Médicinales (CERFOPLAM) - Département de Physiologie/Pharmacologie , EKLU-GADEGBEKU, KWASHIE Faculté des Sciences - Centre de Recherche et de Formation sur les Plantes Médicinales (CERFOPLAM) - Département de Physiologie/Pharmacologie , MOUZOU, AKLESSO Faculté des Sciences - Centre de Recherche et de Formation sur les Plantes Médicinales (CERFOPLAM) - Département de Physiologie/Pharmacologie , AKLIKOKOU, KODJO Faculté des Sciences - Centre de Recherche et de Formation sur les Plantes Médicinales (CERFOPLAM) - Département de Physiologie/Pharmacologie , GBEASSOR, MESSANVI Faculté des Sciences - Centre de Recherche et de Formation sur les Plantes Médicinales (CERFOPLAM) - Département de Physiologie/Pharmacologie
Pages
5
From page
185
To page
189
Abstract
The whole plant of Biophytum petersianum was extracted with a mixture of water & ndash; alcohol (1:1) to evaluate its relaxant effect on aorta rings. In isolated Wistar rat tissue, the hydro-ethanolic extract (0.1; 0.25 and 0.5 mg/ml) non-competitively antagonized calcium chloride and high-K + - induced aorta contractions in a concentration-dependent manner. Moreover, the inhibition of noradrenaline & ndash; induced contractions in the presence of extract (1 mg/ml) suggests that the extract has an effect on mobilization of intracellular calcium. These results indicate that hypotensive effect of Biophytum petersianum may result from inhibition of calcium influx via both voltage-and receptor-operated calcium channels.
Keywords
Biophytum petersianum , Aorta , Calcium antagonistic activity , Hypertension
Journal title
Astroparticle Physics
Serial Year
2007
Record number
2485810
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