Author/Authors :
Binaafar, Sima Department of Biology - Sciences and Research Branch Islamic Azad University, Tehran, Iran , Kalani, Majid Akbarabadi Hospital - Iran University of Medical Sciences, Tehran, Iran , Nayeri, Fatemeh Breast Feeding Research Center - Imam Khomeini Hospital Complex - Tehran University of Medical Sciences, Tehran, Iran , Irani, Shiva Department of Biology - Sciences and Research Branch Islamic Azad University, Tehran, Iran , Salimi, Vahid Department of Virology - School of Public Health - Tehran University of Medical Sciences, Tehran, Iran , Shariat, Mamak Breast Feeding Research Center - Imam Khomeini Hospital Complex - Tehran University of Medical Sciences, Tehran, Iran , Niknafs, Nikoo Department of Virology - School of Public Health - Tehran University of Medical Sciences, Tehran, Iran , Dalili, Hosein Maternal, Fetal and Neonatal Research Center - Imam Khomeini Hospital Complex - Tehran University of Medical Sciences, Tehran, Iran , Amini, Elaheh Maternal, Fetal and Neonatal Research Center - Imam Khomeini Hospital Complex - Tehran University of Medical Sciences, Tehran, Iran , Esmaeilnia Shirvani, Tahereh Maternal, Fetal and Neonatal Research Center - Imam Khomeini Hospital Complex - Tehran University of Medical Sciences, Tehran, Iran , Hardani, Amir-Kamal School of Medicine - Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran , Taheritafti, Roya Department of Pediatrics - Faculty of Medicine - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Ghasemi-Fakhr, Nasrin Maternal, Fetal and Neonatal Research Center - Imam Khomeini Hospital Complex - Tehran University of Medical Sciences, Tehran, Iran , Ghadami, Mohsen Department of Medical Genetics - Faculty of Medicine - Tehran University of Medical Sciences, Tehran, Iran , Tavakkoly-Bazzaz, Javad Department of Medical Genetics - Faculty of Medicine - Tehran University of Medical Sciences, Tehran, Iran , Rashidi-Nezhad, Ali Maternal, Fetal and Neonatal Research Center - Imam Khomeini Hospital Complex - Tehran University of Medical Sciences, Tehran, Iran
Abstract :
Background: Respiratory distress syndrome (RDS) is a major acute postnatal pulmonary disease that influences mostly preterm
neonates. Recently, the polymorphism of immunomodulatory genes has been suggested to be associated with RDS development.
Objectives: We aimed at investigating the association of CNR2 gene Q63R polymorphism with the development of RDS.
Methods: In this multicenter case series study, we enrolled 300 preterm newborns. The RDS was diagnosed based on the clinical
and radiographic findings. The polymerase chain reaction with sequence-specific primer method was used for genotyping.
Results: 140 neonates out of 300 were diagnosed with RDS. The overall frequency of theQQ, QR, and RR genotypes of rs35761398 was
23.7%, 50.7%, and 25.6%, respectively. In the present study, the differences in birth weight, birth height, gestational age (GA), and the
severity of respiratory distress were statistically significant between the two groups.We foundnostatistically significant differences
in either allele (P = 0.624) or genotype (P = 0.461) distributions between the RDS patients and the healthy group.
Conclusions: Gestational age of < 28 weeks has the highest impact on predisposition to RDS. No association was found between
rs35761398 and RDS in a group of Iranian preterm infants.
