Author/Authors :
Amoozgar, Hamid Neonatology and Cardiac Research Center - Shiraz University of Medical Sciences, Shiraz, Iran , Edraki, Mohammad R Neonatology and Cardiac Research Center - Shiraz University of Medical Sciences, Shiraz, Iran , Ayatollahi, Maryam Transplant Research Center of Shiraz University of Medical Sciences, Shiraz, Iran , Borzouee, Mohammad Neonatology and Cardiac Research Center - Shiraz University of Medical Sciences, Shiraz, Iran , Ajami, Gholamhossein Neonatology and Cardiac Research Center - Shiraz University of Medical Sciences, Shiraz, Iran , Mohammadi, Hamid Neonatology and Cardiac Research Center - Shiraz University of Medical Sciences, Shiraz, Iran , Mehdizadegan, Nima Neonatology and Cardiac Research Center - Shiraz University of Medical Sciences, Shiraz, Iran , Shakibazad, Nader Hematology Research Center - Shiraz University of Medical Sciences, Shiraz, Iran , Arabi, Hamid Neonatology and Cardiac Research Center - Shiraz University of Medical Sciences, Shiraz, Iran , Alwesabi, Fatehi Neonatology and Cardiac Research Center - Shiraz University of Medical Sciences, Shiraz, Iran , Naghshzan, Amir Neonatology and Cardiac Research Center - Shiraz University of Medical Sciences, Shiraz, Iran , Keshavarz, Kambiz Neonatology and Cardiac Research Center - Shiraz University of Medical Sciences, Shiraz, Iran
Abstract :
Background: Benefits of stem cell therapy on remodelling and cardiac function have been described in adults with dilated cardiomyopathy
and acute myocardial infarction.
Objectives: We investigated the effect of this treatment modality amongst children with severe dilated cardiomyopathy.
Methods: Intracoronary injection of autologous bone marrow mononuclear stem cells was performed in our centers for 8 severely
ill children during 2015 - 2016. Themeanage of the patients was 10.1 years (5 girls, 3 boys). They were followed by longitudinal speckle
tracking echocardiography (STE) and conventional echocardiography for 6 months.
Results: Heart functional class improved in 62% of patients. M-mode echocardiography showed significant improvement in ejection
fraction (mean 24.88.3 vs. 37.410.5) and in STE, the mean global longitudinal strain improved (GLS: -2.81.9 vs. -5.23.9).
None of the patients had serious complications.
Conclusions: Intracoronary injection of autologous mononuclear stem cells might improve the ventricular function and cardiac
remodelling in pediatric patients with dilated cardiomyopathy and could be considered in critically ill patients.
