Title of article
A Study of Intracoronary Injection of Hematopoietic Stem Cells in Pediatric Dilated Cardiomyopathy: Is It an Applicable Solution for Critically Ill Patients?
Author/Authors
Amoozgar, Hamid Neonatology and Cardiac Research Center - Shiraz University of Medical Sciences, Shiraz, Iran , Edraki, Mohammad R Neonatology and Cardiac Research Center - Shiraz University of Medical Sciences, Shiraz, Iran , Ayatollahi, Maryam Transplant Research Center of Shiraz University of Medical Sciences, Shiraz, Iran , Borzouee, Mohammad Neonatology and Cardiac Research Center - Shiraz University of Medical Sciences, Shiraz, Iran , Ajami, Gholamhossein Neonatology and Cardiac Research Center - Shiraz University of Medical Sciences, Shiraz, Iran , Mohammadi, Hamid Neonatology and Cardiac Research Center - Shiraz University of Medical Sciences, Shiraz, Iran , Mehdizadegan, Nima Neonatology and Cardiac Research Center - Shiraz University of Medical Sciences, Shiraz, Iran , Shakibazad, Nader Hematology Research Center - Shiraz University of Medical Sciences, Shiraz, Iran , Arabi, Hamid Neonatology and Cardiac Research Center - Shiraz University of Medical Sciences, Shiraz, Iran , Alwesabi, Fatehi Neonatology and Cardiac Research Center - Shiraz University of Medical Sciences, Shiraz, Iran , Naghshzan, Amir Neonatology and Cardiac Research Center - Shiraz University of Medical Sciences, Shiraz, Iran , Keshavarz, Kambiz Neonatology and Cardiac Research Center - Shiraz University of Medical Sciences, Shiraz, Iran
Pages
7
From page
1
To page
7
Abstract
Background: Benefits of stem cell therapy on remodelling and cardiac function have been described in adults with dilated cardiomyopathy
and acute myocardial infarction.
Objectives: We investigated the effect of this treatment modality amongst children with severe dilated cardiomyopathy.
Methods: Intracoronary injection of autologous bone marrow mononuclear stem cells was performed in our centers for 8 severely
ill children during 2015 - 2016. Themeanage of the patients was 10.1 years (5 girls, 3 boys). They were followed by longitudinal speckle
tracking echocardiography (STE) and conventional echocardiography for 6 months.
Results: Heart functional class improved in 62% of patients. M-mode echocardiography showed significant improvement in ejection
fraction (mean 24.88.3 vs. 37.410.5) and in STE, the mean global longitudinal strain improved (GLS: -2.81.9 vs. -5.23.9).
None of the patients had serious complications.
Conclusions: Intracoronary injection of autologous mononuclear stem cells might improve the ventricular function and cardiac
remodelling in pediatric patients with dilated cardiomyopathy and could be considered in critically ill patients.
Keywords
Dilated Cardiomyopathy , Speckle Tracking Echocardiography , Stem Cell Therapy
Journal title
Astroparticle Physics
Serial Year
2019
Record number
2486328
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