Title of article :
Association Between the Common Carotid Artery Intima-Media Thickness and Glucose Metabolism in Obese Children
Author/Authors :
Lee, Ju-Hyung Department of Preventive Medicine - Chonbuk National University Medical School, Jeonju, Korea , Lee, Sun Hwa Department of Internal Medicine - Chonbuk National University Medical School, Jeonju, Korea , Kwon, Keun Sang Department of Preventive Medicine - Chonbuk National University Medical School, Jeonju, Korea , Joo, Chan Uhng Department of Pediatrics - Chonbuk National University Medical School, Jeonju, Korea , Lee, Dae-Yeol Department of Pediatrics - Chonbuk National University Medical School, Jeonju, Korea , Kim, Min Sun Department of Pediatrics - Chonbuk National University Medical School, Jeonju, Korea
Abstract :
Objectives: To determine the relationship between glucose metabolism and atherosclerosis assessed according to the common
carotid artery intima-media thickness (CIMT) in non-diabetic obese children.
Methods:We performed anthropometric measurements and laboratory tests, including the oral glucose tolerance test (OGTT). The
CIMTs on both sides were measured in obesity (body mass index [BMI] 95 percentile) children by one researcher.
Results: There were 44 boys and 22 girls, and the mean age was 10.732.48 years (range, 8 - 14 years). The mean CIMT on both sides,
age, BMI, blood pressure, lipid profile, OGTT results, and HbA1c level were not significantly different between the boys and girls.
Simple correlation analyses showed that the fasting plasma glucose (PG) level (
= 0.266, P = 0.034), PG at 90 min (
= 0.318, P =
0.014), PG at 120 min (
= 0.336, P = 0.009), HbA1c level (
= 0.306, P = 0.015), PG increase at 90 min (PG90) (
= 0.310, P = 0.017),
and PG120 (
= 0.338, P = 0.009) were significantly correlated with the left CIMT. In multiple regression analysis, the HbA1c level,
PG90, and PG120 were significantly associated with the left CIMT (P < 0.01).
Conclusions: Ultrasound-measured CIMT, especially the left CIMT, is a reasonable glucose metabolic indicator of atherosclerotic
vascular complications in obese children.
Keywords :
Oral Glucose Tolerance Test , Obesity , Glycated Hemoglobin , Children , Carotid Intima-Media Thickness
Journal title :
Astroparticle Physics