Author/Authors :
Srinivas, Srilatha Parampalli Dept. of Pathology- Kastura Medical College- Manipal University, Manipal, Karnataka, India , Das, Jayitri Kasturba Medical College- Manipal University, Manipal, Karnataka , India , Monappa, Vidya Department of Pathology- Kasturba Medical College- Manipal University, Manipal, Karnataka, India
Abstract :
Medullary thyroid carcinoma (MTC) is a rare tumor arising from parafollicular
C-cells. The oncocytic variant of MTC is an extremely rare diagnosis, with less than
20 cases reported. Here we present the case of a 36-year-old male patient with complaints
of neck swelling and dysphagia. On fine needle aspiration cytology (FNAC),
a Hürthle cell neoplasm was suggested. Finally with histopathology and immunohistochemistry
(IHC), a diagnosis of MTC oncocytic variant was established. This tumor
can be easily misdiagnosed for any thyroid Hürthle cell lesions. An accurate diagnosis
is important because MTC has different treatment protocols, and its oncocytic variant
is expected to be associated with poorer patient survival. Thus, the oncocytic variant
of MTC is a difficult diagnosis on FNAC. Histopathology and relevant IHC markers
are necessary for a correct diagnosis.
