Author/Authors :
Rajizadeh, Mohammad Amin Physiology Research Center - Institute of Basic and Clinical Physiology Sciences - Kerman University of Medical Sciences, Kerman, Iran , Najafpour, Hamid Department of Physiology - Afzalipour Medical Faculty - Kerman University of Medical Sciences, Kerman, Iran , Samareh Fekri, Mitra Kerman University of Medical Sciences, Kerman, Iran , Rostamzadeh, Farzaneh Institute of Basic and Clinical Physiology Sciences - Kerman University of Medical Sciences, Kerman, Iran , Jafari, Elham Department of Pathology and Pathology and Stem Cells Research Center - Kerman University of Medical Science, Kerman, Iran , Bejeshk, Mohammad Abbas Gastroenterology and Hepatology Research Center - Institute of Basic and Clinical Physiology Sciences - Kerman University of Medical Sciences, Kerman, Iran , Masoumi Ardakani, Yaser Physiology Research Center - Institute of Basic and Clinical Physiology Sciences - Kerman University of Medical Sciences, Kerman, Iran
Abstract :
The aim of the present study was to investigate the effect of Myrtenol, the active ingredient
of Myrtle on the oxidant and anti-oxidant indices and cytokines in the allergic asthma. Allergic
asthma was induced by ovalbumin (OVA) sensitization and inhalation in four groups of rats;
Control, Asthma, Asthma + Dexamethasone and Asthma + Myrtenol. Myrtenol (50mg/kg) or
Dexamethasone (2.5mg/kg) was administered intraperitoneally for 7 consecutive days after
OVA inhalation. At the end, histopathological parameters, and interleukins (Interleukin-10
(IL10), Interferon gamma (IFN-γ) , interleukin-1β (IL-1β), Tumor Necrosis Factor α (TNF-α)),
and oxidative stress biomarkers, Malondialdehyde (MDA), superoxide dismutase (SOD) and
glutathione peroxidase (GPX) in the lung and serum were measured by hematoxylin and eosin
staining and ELISA method, respectively. Myrtenol reduced the pathological changes in the
lungs and airway endothelium (P < 0.01), (P < 0.5). The level of IL-1β (P < 0.05) and MDA
in the serum and lung tissue (P < 0.01), (P < 0.05), and also the level of TNF-α (P < 0.05)
in the lung tissue decreased in the Myrtenol group compared to the asthma group. Myrtenol
increased the level of IL-10 (P < 0.05) and the activity of GPX in the lung tissue and serum (P
< 0.001). Myrtenol may improve asthma by increasing the ratio of antioxidants to oxidants and
reducing the ratio of pro-inflammatory to anti-inflammatory interleukins in the lung. Myrtenol
is presented as a potent herbal medicine ingredient for the treatment of asthma.
Keywords :
Cytokines , Glutathione peroxidase , Superoxide dismutase , Malondialdehyde , Allergic asthma , Myrtenol
