Author/Authors :
Hamzian, Nima Department of Medical Physics - Faculty of Medicine - Shahid Sadoughi University of Medical Sciences, Yazd, Iran , Hashemi, Maryam Nanotechnology Research Center - Institute of Pharmaceutical Technology - Mashhad University of Medical Sciences, Mashhad, Iran , Ghorbani, Mahdi Department of Biomedical Engineering and Medical Physics - Faculty of Medicine - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Aledavood, Amir Cancer Research Center - Mashhad University of Medical Sciences, Mashhad, Iran , Ramezani, Mohammad Department of Pharmaceutical Biotechnology - School of Pharmacy - Mashhad University of Medical Sciences, Mashhad, Iran , Bahreyni Toosi, Mohammad Hossein Medical Physics Research Center - Faculty of Medicine - Mashhad University of Medical Sciences, Mashhad, Iran
Abstract :
This study aimed to modify the biological response of cells to ionizing radiation by
combination therapy using radio-sensitizer agent and anticancer drug. Super paramagnetic
iron oxide nanoparticles (SPIONs) were prepared and used with gemcitabine (Gem). These
two agents were encapsulated simultaneously intopoly (D, L-lactic-co-glycolic acid) (PLGA)
to form multifunctional drug delivery system. The physicochemical characteristics of the
nanoparticles (NPs) were studied. The dose enhancement ratio (DER) of various treatment
groups was calculated and compared using human breast cancer cell line (MCF-7). The DER for
PLGA-SPION-Gem was the highest at 1 Gy60Co (3.18). Cumulative effect from simultaneous
use of two radiosensitizer (Gem and SPIONs) was observed. Thus, we have successfully
developed PLGA NPs loaded with gemcitabine and SPIONas a radiosensitizersystem which
potentially could be used in radiotherapy.
Keywords :
Radiosensitizer , Radiotherapy , Gemcitabine , SPION-PLGA , Multifunctional drug delivery system
