• Title of article

    Association Between HLA-B Polymorphisms and Autism Spectrum Disorder in Chinese Population

  • Author/Authors

    Kang, Guojun School of Public Health - Jilin University, Changchun, China , Kang, Qi School of Public Health - Jilin University, Changchun, China , Zhu, Xiaojing School of Public Health - Jilin University, Changchun, China , Li, Rixin School of Public Health - Jilin University, Changchun, China , Zhang, Shangchao School of Public Health - Jilin University, Changchun, China , Sun, Yaoyao School of Public Health - Jilin University, Changchun, China , Zhang, MIngyuan School of Public Health - Jilin University, Changchun, China , Chen, Xin School of Public Health - Jilin University, Changchun, China , Wang, Yueying School of Public Health - Jilin University, Changchun, China , Jiang, Huiyi Department of Pediatrics - Second Part of First Hospital - Jilin University, Changchun, China , Yu, Yaqin School of Public Health - Jilin University, Changchun, China , Yu, Qiong School of Public Health - Jilin University, Changchun, China

  • Pages
    6
  • From page
    1
  • To page
    6
  • Abstract
    Objectives: The aim of this study was to investigate the association between 2 single-nucleotide polymorphisms (SNP) of HLA-B and autism spectrum disorder (ASD). Methods:We enrolled 84 ASD and 182 healthy children in case-control study, and 67 family trios in family-based study. Two tag SNPs (rs1058026, rs2770) in gene HLA-B were selected to determine the association with ASD. Chi-square test was used in case-control study, haplotype relative risk test (HRR) and transmission disequilibrium test (TDT) analysis were performed in family-based study. Results: SNP rs1058026 was found significantly associated with ASD in family-based study (P = 0.016 for HRR; P = 0.020 for TDT), but not in case-control study. Conversely, SNP rs2770 did not show association with ASD in both studies. Conclusions: The association observed from this study indicates that gene HLA-B might play a role in ASD in Chinese population.
  • Keywords
    HLA-B , Human Leukocyte Antigen , Single-Nucleotide Polymorphisms , Autism Spectrum Disorder
  • Journal title
    Astroparticle Physics
  • Serial Year
    2020
  • Record number

    2487228

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=2487228