Author/Authors :
TAVAKKOL AFSHARI, Zeinab Department of Immunogenetic and Cell Culture - Immunology Research Center - School of Medicine - Mashhad University of Medical Sciences, Mashhad , GHOLIZADEH, Zahra Department of Immunogenetic and Cell Culture - Immunology Research Center - School of Medicine - Mashhad University of Medical Sciences, Mashhad , NIKPOOR, Amin Reza Hormozgan University of Medical Sciences, Bandar Abbas , TAVAKKOL AFSHARI, Jalil Department of Immunogenetic and Cell Culture - Immunology Research Center - School of Medicine - Mashhad University of Medical Sciences, Mashhad , GANJALI, Rashin Department of Immunogenetic and Cell Culture - Immunology Research Center - School of Medicine - Mashhad University of Medical Sciences, Mashhad , HOMAEI SHANDIZ, Fatemeh Mashhad University of Medical Sciences, Mashhad , JAMIALAHMADI, Khadijeh Department of Medical Biotechnology and Nanotechnology - School of Medicine - Mashhad University of Medical Sciences, Mashhad
Abstract :
Background: The tumor protein p73 (TP73) is a homolog of TP53 family. Ectopic p73 overexpression largely mimics p53 activities as a tumor suppressor and activates the transcription of p53-responsive genes and as a result induce apoptosis. This study aimed to investigate the association between p73 G4A polymorphism and the risk of breast cancer in a northeastern Iranian population.
Methods: This case-control study was performed on 105 patients who admitted in educational hospitals of Mash-had University of Medical Sciences, Iran during 2013-2015, with breast cancer as case group and 120 healthy women as the control group. PCR-CTPP method was used to investigate the relationship between the p73 G4A polymorphism and the risk of breast cancer.
Results: There was no significant association between the AA genotype of the p73 G4A polymorphism and breast cancer in case and control groups. Although G allele frequency was higher in the case group, the abundance of this allele between case and control groups was not statistically meaningful and, as a result, not associated with the risk of breast cancer in this study group.
Conclusion: There was no association between G4A p73 polymorphism and the risk of breast cancer in a north-eastern Iranian population.
