Author/Authors :
Emami, Ahmad Department of Traditional Pharmacy - School of Pharmacy - Mashhad University of Medical Sciences, Mashhad, Iran , Kheshami, Shima Department of Traditional Pharmacy - School of Pharmacy - Mashhad University of Medical Sciences, Mashhad, Iran , Ramazani, Elham Department of Biology - Faculty of Science - Ferdowsi University of Mashhad, Mashhad, Iran , Akaberi, Maryam Department of Traditional Pharmacy - School of Pharmacy - Mashhad University of Medical Sciences, Mashhad, Iran , Iranshahy, Milad Department of Traditional Pharmacy - School of Pharmacy - Mashhad University of Medical Sciences, Mashhad, Iran , Kazemi, Mahammad Department of Traditional Pharmacy - School of Pharmacy - Mashhad University of Medical Sciences, Mashhad, Iran , Tayarani Najaran, Zahra Medical Toxicology Research Center - Mashhad University of Medical Sciences, Mashhad, Iran
Abstract :
Chaharmahal and Bakhtiari Province is one of the most important endemism states of the
flora of Iran with a considerable plant species diversity. In the present study, the cytotoxic
activity of 13 plant species grown in Chaharmahal and Bakhtiari have been evaluated on
prostate (PC-3), breast (MCF-7), liver (HepG2), ovary (CHO), and melanoma (B16-F10)
cancer cell lines. The cytotoxicity and apoptotic activity of methanol extracts was evaluated
using resazurin reagent and flow cytometry of PI stained cells, respectively. Methanol extracts
of Dionysia sawyeri, Stachys obtusicrena and Cicer oxyodon on CHO cell line (p <0.05) and D.
sawyer and Linum album on B16/F10 cell line (p <0.05) showed significant cytotoxic effects
and increased apoptosis. It is generally suggested that the plant extracts with low IC50 values
are likely to be used as anti-cancer compounds in reducing cancer progression in scientific
studies.
Keywords :
Apoptosis , Cytotoxic , Tanacetum , Scutellaria , Phlomis , Achillea , Nepeta
