Author/Authors :
Mahmoudi, Mahdi Rheumatology Research Center, Tehran University of Medical Sciences , Ebrahimiyan, Hamidreza Rheumatology Research Center, Tehran University of Medical Sciences , Aslani, Saeed Rheumatology Research Center, Tehran University of Medical Sciences , Jamshidi, Ahmadreza Rheumatology Research Center, Tehran University of Medical Sciences , Mostafaei, Shayan Department of Community Medicine - School of Medicine - Kermanshah University of Medical Sciences - Kermanshah, Iran
Abstract :
STAT4 is a transcription factor that plays a role in various cytokine
signaling pathways and in T cell subsets differentiation. Several studies have reported
STAT4 gene polymorphism in association with various autoimmune diseases.
Objective: To evaluated the association between STAT4 rs7574865 SNP and RA risk
by meta-analysis. Methods: Two major databases, namely Scopus and PubMed, were
searched to find studies investigating the STAT4 polymorphism and RA in different
populations up to November 2017. Association between STAT4 polymorphism and RA
were analyzed using pooled odds ratio (OR) and their corresponding 95% CI. Results:
In this meta-analysis, 21 population studies (16 papers) comprising 15,732 cases and
15641 healthy subjects evaluating the STAT4 gene rs7574865 SNP were included based
on inclusion criteria. Herein, we found a significant positive association between minor
T allele as well as different genotypes with the risk of RA. Conclusions: In summary,
this study revealed an association between STAT4 gene rs7574865 SNP and risk of RA.
Keywords :
Single Nucleotide , Rs7574865 - STAT4 , Rheumatoid Arthritis , Meta-Analysis
