Author/Authors :
Alyasin, Soheila Allergy Research Center - Shiraz University of Medical Sciences, Shiraz , Abbasi, Reza Allergy Research Center - Shiraz University of Medical Sciences, Shiraz , Esmaeilzadeh, Hossein Allergy Research Center - Shiraz University of Medical Sciences, Shiraz , Nabavizadeh, Hesamedin Allergy Research Center - Shiraz University of Medical Sciences, Shiraz , Zomorodian, Kamiar Basic Sciences in Infectious Diseases Research Center , Zare Shahrabadi, Zahra School of Public Health - Shiraz University of Medical Sciences, Shiraz , Saadat, Farshid Department of Immunology - School of Public Health - Guilan University of Medical Sciences - Guilan, Iran
Abstract :
Fungal aeroallergens might sensitize the airway which in turn produces a
specific cytokine profile. Objective: To evaluate the IL-25 and IL-33 profile in patients
with fungal allergic rhinitis. Methods: The present study examined patients who were
evaluated due to allergic rhinitis (AR) at Emam Reza Hospital of Shiraz, Iran. The
allergic patients were categorized based on the skin prick test. Blood samples were
collected and allergen-specific IgE and cytokine profiles were analyzed. Results: 184
patients were enrolled in the study and in 35 of whom fungal rhinitis was confirmed.
The levels of specific IgE in patients with fungal allergy were statistically significant
compared to those in the control group (p<0.000). However, there were no significant
differences in IL-25 and IL-33 levels between fungal and none-fungal AR patients.
Conclusion: Chronic fungal challenge might regulate innate system cytokines in severe
persistent AR.
Keywords :
Interleukin-33, IgE , Interleukin-25 , Allergic Fungal Sinusitis
