The Effect of Endurance Training and Crocin Consumption on Anxiety-like Behaviors and Aerobic Power in Rats with Alzheimer’s

background:anxiety, depression, and physical problems are the problems of patients with alzheimer’s disease (ad). it has been reported that exercises and crocin consumption can improve the anxietylike behaviors and aerobic power in patients with ad.objectives:the present study aimed to investigate the interactive effect of endurance training and crocin on anxietylike behaviors and aerobic power of rats with ad.methods:in this experimental study, 40 male rats with ad (with mean age of eight weeks) were divided into five groups, including (1) control (c), (2) endurance training (et), (3) endurance training and crocin (etcr), (4) crocin (cr), and (5) sham (sh). during eight weeks, the rats in groups 2 and 3 ran on treadmill for three sessions per week and groups 3 and 4 received 25 mg/kg of crocin peritoneally each day. anxietylike behaviors were assessed by elevated plusmaze and aerobic power test using rats’ treadmill test.results:endurance training significantly decreased weight and anxietylike behaviors as well as increased aerobic power (p ≤ 0.05); crocin significantly decreased anxietylike behaviors and increased aerobic power (p ≤ 0.05); however, the interaction of endurance training and crocin consumption were not significant in the reduction of weight and anxietylike behaviors and increase of aerobic power (p ≤ 0.05).conclusions:it seems that endurance training and crocin consumption distinctly function and from different pathways effective in decreasing anxiety and increasing aerobic power in rats with ad.