Author/Authors :
Enayati, Hoda Mashhad University of Medical Sciences , Ayatollahi, Hossein Cancer Molecular Pathology Research Center - Mashhad University of Medical Sciences , Keramati, Mohammad Reza Cancer Molecular Pathology Research Center - Mashhad University of Medical Sciences , Sheikhi, Maryam Cancer Molecular Pathology Research Center - Mashhad University of Medical Sciences , Bagheri, Hassan Mashhad University of Medical Sciences , Shams, Fatemeh Cancer Molecular Pathology Research Center - Mashhad University of Medical Sciences , Sadeghian, Mohammad Hadi Cancer Molecular Pathology Research Center - Mashhad University of Medical Sciences
Abstract :
Background: Acute lymphoblastic leukemia (ALL) results from genetic
alterations in a single lymphoid progenitor cell. Expression of ROR1 is reported
to be increased in ALL and mantle cell lymphoma. In this study the expression
of ROR1 was assessed in newly diagnosed patients with ALL.
Methods: This study was carried out on 40 patients with newly diagnosed
ALL and healthy individuals as control group. Quantification of ROR1 mRNA
expression by Real Time quantitative PCR was performed. The expressions of
ROR gene in patients were compared with the control group.
Results: ROR1 mRNA expression (Fold Changes) in patients with ALL was
2.85±3.51. ROR1 mRNA expression in patients with ALL was significantly higher
than normal individuals (P<0.001). There was not any relationship between the
expression of ROR1 and cytogenetic abnormalities.
Conclusion: We assessed ROR1 gene expression on mRNA of 40 ALL patients at
diagnosis. The results showed that ROR1 expression had significant increase in
ALL patients compared with healthy controls.
Keywords :
Acute lymphoblastic leukemia , Receptor tyrosine kinase-like orphan , receptor 1 , Gene expression
