Author/Authors :
Rezvani, Alireza Assistant Professor of Hematology and Oncology - Shiraz Hematology Research Center, Shiraz , Fakhar, Reza MD Graduate of Shiraz University of Medical Sciences, Shiraz , Taherifard, Ehsan Medical Student at Shiraz University of Medical Sciences, Shiraz , Habibagahi, Zahra Assistant Professor of Rheumatology - Department of Internal Medicine - Shiraz University of Medical Sciences , Taherifard, Erfan Medical Student at Shiraz University of Medical Sciences, Shiraz
Abstract :
Background: Considering the role of Duffy antigenic system expression on
RBCs as chemokines for inflammatory cytokines, expression of Duffy antigens
as different phenotypes was studied in a group of patients with SLE. The
association between different phenotypes of Duffy antigens and occurrence of
SLE and its severity was assessed.
Methods: This cross-sectional study was carried out on 100 patients diagnosed
as SLE using the “Systemic Lupus International Collaborating Clinics 2012
(SLICC) classification” criteria and 100 age-matched healthy subjects as control
from April to June 2017. Duffy blood group status was determined in both
groups. The patients were categorized into three groups of mild, moderate and
severe according to “Systemic Lupus Erythematosus Disease Activity Index
2000 (SLEDAI-2K)” scores.
Results: The results of this study showed no significant association between the
three different phenotypes of Duffy antigen system and increased risk of SLE or
its severity.
Conclusion: The results of the current study did not approve of any association
between three different Duffy phenotypes and increased risk of SLE or its
severity.
Keywords :
Systemic lupus erythematosus , Duffy blood group system , DARC antigen , Blood group antigens , Association
