Author/Authors :
HADJ KACEM, Faten Department of Endocrinology - Hedi Chaker Hospital - Sfax, Tunisia , CHEBBI, Donia Department of Endocrinology - Hedi Chaker Hospital - Sfax, Tunisia , CHAKROUN, Amal Department of Endocrinology - Hedi Chaker Hospital - Sfax, Tunisia , CHARFI, Nadia Department of Endocrinology - Hedi Chaker Hospital - Sfax, Tunisia , GHORBEL, Dorra Department of Endocrinology - Hedi Chaker Hospital - Sfax, Tunisia , MNIF, Fatma Department of Endocrinology - Hedi Chaker Hospital - Sfax, Tunisia , MNIF, Mouna Department of Endocrinology - Hedi Chaker Hospital - Sfax, Tunisia , REKIK, Nabila Department of Endocrinology - Hedi Chaker Hospital - Sfax, Tunisia , ABID, Mohamed Department of Endocrinology - Hedi Chaker Hospital - Sfax, Tunisia
Abstract :
VIPoma is an unusual neuroendocrine neoplasm that autonomously secretes VIP. It is associated with secretory diarrhea and electrolyte disturbances. Herein we report a case of a male patient, who was hospitalized in the De-partment of Endocrinology in Hedi Chaker Hospital, Sfax, Tunisia. He presented VIPoma syndrome, with hepat-ic metastases at diagnosis. He had a history of chronic, watery diarrhea. He was dehydrated with many electrolytic disorders as hypokalemia, hyponatremia and metabolic acidosis. Abdominal CT scan showed a heterogene-ous mass in the pancreatic head with multiple hepatic lesions. A high VIP hormone level was found. Histological study of a liver biopsy revealed hepatic metastases of neuroendocrine carcinoma. The patient received analogues of somatostatin and systemic chemotherapy, with a transient symptomatic relief. Sadly the patient was lost to fol-low-up.
Keywords :
Neuroendocrine tumor , Somatostatin analogue , Vipoma , Secretory diarrhea , Tunisia
