Title of article :
The Effect of Gradual Reduction in Sodium Dialysate on Occurrence of Muscular Cramp, and the Serum Level of Calcium and Magnesium in Patients Undergoing Hemodialysis: A Cross-Over Clinical Trial
Author/Authors :
Majidi, Uosra Student Research Committee - School of Nursing and Midwifery - Shahroud University of Medical Sciences , Amerian, Monireh Clinical Research Development Unit - Imam Hossein Hospital - Shahroud University of Medical Sciences , Khosravi, Farideh School of Public Health - Shahroud University of Medical Sciences , Abbasi, Ali School of Nursing and Midwifery - Shahroud University of Medical Sciences , Khajeh, Mahboobeh School of Nursing and Midwifery - Shahroud University of Medical Sciences , Ebrahimi, Hossein Clinical Trial Research Center - Shahroud University of Medical Sciences
Abstract :
Background: The aim of study was to determine the effect of gradual
reduction in sodium dialysate on occurrence of muscular cramp, and
the serum level of calcium and magnesium in patients undergoing
hemodialysis.
Methods: This triple-blinded cross-over clinical trial was conducted on
56 hemodialysis patients. After random allocation of patients into
group A by the routine method (fixed sodium dialysate) and group B
with gradual reduction in sodium dialysate, they underwent a 3-session
dialysis. After one week of dialysis through routine method (wash out),
patients underwent 3-session dialysis in group B by routine method and
in group A by gradual reduction in sodium dialysate. Occurrence of
muscular cramp was recorded by using a check list. Patients, serum
level of calcium and magnesium before and after intervention was
measured. Descriptive statistics indices and inferential statistics tests
(repeated measures Analysis of variance) were used.
Results: The rate of muscular cramp in routine method was 3.8% in
one muscle, 1.9% in two or more muscles, and in the method of
gradual reduction of sodium dialysate was 1.9% in one muscle, and
7.5% in two or more muscles. The mean difference of plasma calcium
and magnesium before and after the dialysis with routine method was
0.43 and 0.26, respectively, and in the method of gradual reduction of
sodium dialysate was 0.45 and 0.34. In this study no significant
difference was observed for the rate of occurrence of muscular cramp
and serum level of calcium and magnesium between two methods.
Conclusions: The results showed that gradual reduction of sodium
dialysate, has no effect on occurrence of muscular cramp during
dialysis, serum level of calcium and magnesium in hemodialysis
patients. Further investigations are needed to better understand the
exact effect of this method, and also eliminate the study limitations.
Keywords :
Calcium , Hemodialysis , Magnesium , Muscle cramp , Sodium dialysate
Journal title :
Astroparticle Physics
