Title of article :
Low Birth Weight, and Low Ponderal Index Mediates the Association between Preeclampsia, Placenta Previa, and Neonatal Mortality
Author/Authors :
WAN, NAWSHER Department of Preventive Medicine - School of Health Sciences - Wuhan University - Wuhan - Hubei, China , KHAN, Abbas Department of Food Science - College of Food Science and Engineering - Jilin University, Changchun, China , BEGUM, Nabila Department of Advanced Innovation Center for Food Nutrition and Human Health - Laboratory of Molecular Sensory Science - College of Food and Chemical Engineering - Beijing Technology and Business University - Beijing, China , AHMED, Zahoor Department of Food Science - School of Food Science and Engineering - South China University of Technology - Guangzhou, China , MUBARIK, Sumaira Department of Epidemiology and Biostatistics - School of Health Sciences - Wuhan University - Wuhan - Hubei, China , Ul HAQ, Ijaz Department of Food Science - College of Food and Pharmaceutical Science - Huaian - Jiangsu, China , NABI, Ghulam Hebei Normal University - Shijiazhuang, China , ULLAH, Naeem Department of Nutrition and Food Hygiene - School of Public Health - Jilin University - Changchun, China , FAN, Cuifang Department of Obstetrics and Gynecology - Renmin Hospital - Wuhan University - Wuhan - Hubei, China , WANG, Suqing Department of Preventive Medicine - School of Health Sciences - Wuhan University - Wuhan - Hubei, China
Abstract :
Background: A retrospective study was conducted to assess the mediation role of low birth weight, and low
ponderal index between the preeclampsia, placenta previa, and neonatal mortality in the tertiary hospital of Hubei
Province, China.
Methods: A total of 12772 neonatal births were included for data analysis. Birth weight, birth length, and neonatal
mortality were recorded after birth. Sobel test based on mediation regression was used to evaluate the effect
of mediator variables.
Results: Approximately, 383 (3%) and 409 (3.2%) women experienced preeclampsia and placenta previa respectively.
After adjusting for covariates, the indirect effect of preeclampsia on neonatal mortality mediated by low
birth weight and low ponderal index was [β 2.59 (95% CI: 0.74 – 4.44)], and [β 3.94 (95% CI: 1.50 – 6.38)] respectively.
Moreover, the indirect effect of placenta previa on neonatal mortality mediated by the low birth
weight was [β 1.74 (95% CI: 0.16 – 3.31)], and low ponderal index was [β 3.21 (95% CI: 0.95 – 5.48)]. The estimated
mediation proportion between the preeclampsia and neonatal mortality accounting for possible mediation
by low birth weight and low ponderal index was 44.5% and 34.5% respectively. Furthermore, 47.9% by low birth
weight and 33.2% by low ponderal index mediate the association between placenta previa and neonatal mortality.
Conclusion: Low birth weight, and low ponderal index partially mediates the association between preeclampsia,
placenta previa and neonatal mortality.
Keywords :
Low birth weight , Low ponderal index , Preeclampsia , Placenta previa , Neonatal mortality
