Title of article :
Chest Pain is Associated With Decreased Irisin Serum Levels in Type 2 Diabetic Patients With Coronary Artery Disease
Author/Authors :
Zyaddini, Taybeh Neuroscience Research Center - Institute of Neuropharmacology - Kerman University of Medical Sciences, Kerman, IR Iran , Asadikaram, Gholamreza Endocrinology and Metabolism Research Center - Institute of Basic and Clinical Physiology Sciences and Department of Biochemistry - Afzalipur Faculty of Medicine - Kerman University of Medical Sciences, Kerman, IR Iran , Masoumi, Mohammad Cardiovascular Research Center - Institute of Basic and Clinical Physiology Sciences - Kerman University of Medical Sciences, Kerman, IR Iran
Abstract :
Background: This study aimed to determine irisin serum levels in type 2 diabetic patients with
and without coronary artery disease (CAD).
Methods: This study was performed on 56 type 2 diabetic patients with and without CAD and 28
normal controls. The serum levels of irisin, HbA1c, and fasting blood sugar of all the
participants and the severity of CAD in the diabetic patients were determined.
Results: The irisin serum level was significantly decreased in the CAD diabetic patients who
were symptomatic. HbA1c had a moderate positive correlation with the SYNTAX score
in the diabetic patients with CAD. The serum level of irisin was not significantly
different between the evaluated groups.
Conclusions: Based on the results, decreased irisin may be considered a risk factor for type 2
diabetic patients with CAD. Accordingly, the evaluation of patients with decreased irisin
serum levels regarding the prediction of heart infarcts may be valuable.
Keywords :
Angiography , Cardiovascular diseases , Type 2 diabetes , Irisin
Journal title :
Astroparticle Physics
