Author/Authors :
Elshorbagy, Hatem Hamed Pediatric department - Menofia University - Minufya, Egypt , Barseem, Naglaa Fathy Pediatric department - Menofia University - Minufya, Egypt , Suliman, Hany Abdelaziz Pediatric department - Benha University - Minufya, Egypt , Talaat, Eman Ain shams University - Pediatric department - Cairo, Egypt , Alshokary, Ashraf Hamed Pediatric department - Benha University - Minufya, Egypt , Abdelghani, Waleed Elsayed Pediatric department - Benha University - Minufya, Egypt , Abdulsamea, Sameh Elsayed Pediatric department - Benha University - Minufya, Egypt , Abdel Maksoud, Yehia Hamed Pediatric department - Benha University - Minufya, Egypt , Azab, Sanaa Mohammed Department of Pediatric - Faculty of Medicine - Al-azhar University - Cairo, Egypt , Elsadek, Akram Elshafey Pediatric department - Benha University - Minufya, Egypt , Nour El Din, Dalia Mohamed Clinical pathology-department - Benha University - Minufya, Egypt
Abstract :
Objectives
To investigate the effects of traditional antiepileptic drugs (AEDs)
versus newer AEDs on the thyroid hormone profile of children with
epilepsy.
Materials & Methods
A total of 80 children with epilepsy were included in this study and
were divided into two groups. Group 1 included 40 children with
epilepsy on traditional AEDs, and group 2 included 40 children with
epilepsy on newer AEDs. Forty healthy children were also included
as the control group (group 3). We analyzed the serum levels of free
triiodothyronine (FT3), free thyroxine (FT4), and thyroid stimulating
hormone (TSH). Results
In epileptic children treated with traditional drugs, there was a
significant reduction in the serum level of FT4 and a significant
increase in TSH concentration, compared to the control group
(P<0.001). Conversely, epileptic children treated with newer AEDs
showed no significant changes in the serum concentrations of FT3,
FT4, and TSH, compared to the control group.
Conclusion
Traditional AEDs have more significant effects on thyroid hormone
profile, compared to newer AEDs.
Keywords :
Antiepileptic drugs , Thyroid function , Subclinical hypothyroidism , Children
