Title of article :
Utility of Seizure Pattern and Related Clinical Features in the Diagnosis of Neurometabolic Disorders
Author/Authors :
Jafari, Narjes Department of Pediatric Neurology - Pediatric Neurology Research Center - Research Institute for Children’s Health - Shahid Beheshti University of Medical Sciences, Tehran , Mosallanejad, Asieh Pediatric endocrinology and metabolism Department - Mofid Children's Hospital - Shahid Beheshti university of medical science , Tehran , Ghobadifar, Asieh Department of Pediatric Neurology - Pediatric Neurology Research Center - Research Institute for Children’s Health - Shahid Beheshti University of Medical Sciences, Tehran , Karimzadeh, Parvaneh Pediatric Neurology Department - Mofid Children’s Hospital - Faculty of Medicine - Shahid Beheshti University of Medical Sciences, Tehran , Ghodssi-Ghassemabadi, Robabeh Department of Biostatistics - Faculty of Medical Sciences - Tarbiat Modares University, Tehran , Nasehi, Mohammad mehdi Department of Pediatric Neurology - Pediatric Neurology Research Center - Research Institute for Children’s Health - Shahid Beheshti University of Medical Sciences, Tehran , Shakiba, Marjan Pediatric endocrinology and metabolism Department - Mofid Children's Hospital - Shahid Beheshti university of medical science , Tehran , Tabatabaee, Shahrzad Imam Hosein Medical Center - Shahid Beheshti University of Medical Sciences, Tehran
Pages :
10
From page :
123
To page :
132
Abstract :
Objectives The current study aimed at identifying the role of seizure types and related clinical features in differentiation between neurometabolic disorders and other causes of seizure. Materials & Methods The current cross sectional study was conducted at two referral children hospitals in Tehran, Iran, from 2011 to 2018. The study population included 120 patients presenting with seizure due to neurometabolic disorders and 120 cases due to other causes. The types of seizure and related clinical findings were assessed in both groups. Results There was a significant difference in the frequency of seizure types in the two groups. Tonic and myoclonic seizures as well as infantile spasm were observed more commonly in the patients with neurometabolic disorders, while atonic, partial and generalized tonic-clonic seizures were more common in the control group. In addition, frequency of refractory seizure, age at onset of seizure, and pattern of involvement in brain imaging were helpful for seizure differentiation. Conclusion The pattern of seizure and related findings varied in patients with metabolic disorders, and was helpful for seizure differentiation. Thus, these factors can contribute to early diagnosis and treatment.
Keywords :
Seizure , Children , Neurometabolic , Disorders
Journal title :
Astroparticle Physics
Serial Year :
2020
Record number :
2490438
Link To Document :
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