Author/Authors :
Jafari, Narjes Department of Pediatric Neurology - Pediatric Neurology Research Center - Research Institute for Children’s Health - Shahid Beheshti University of Medical Sciences, Tehran , Mosallanejad, Asieh Pediatric endocrinology and metabolism Department - Mofid Children's Hospital - Shahid Beheshti university of medical science , Tehran , Ghobadifar, Asieh Department of Pediatric Neurology - Pediatric Neurology Research Center - Research Institute for Children’s Health - Shahid Beheshti University of Medical Sciences, Tehran , Karimzadeh, Parvaneh Pediatric Neurology Department - Mofid Children’s Hospital - Faculty of Medicine - Shahid Beheshti University of Medical Sciences, Tehran , Ghodssi-Ghassemabadi, Robabeh Department of Biostatistics - Faculty of Medical Sciences - Tarbiat Modares University, Tehran , Nasehi, Mohammad mehdi Department of Pediatric Neurology - Pediatric Neurology Research Center - Research Institute for Children’s Health - Shahid Beheshti University of Medical Sciences, Tehran , Shakiba, Marjan Pediatric endocrinology and metabolism Department - Mofid Children's Hospital - Shahid Beheshti university of medical science , Tehran , Tabatabaee, Shahrzad Imam Hosein Medical Center - Shahid Beheshti University of Medical Sciences, Tehran
Abstract :
Objectives
The current study aimed at identifying the role of seizure types and
related clinical features in differentiation between neurometabolic
disorders and other causes of seizure.
Materials & Methods
The current cross sectional study was conducted at two referral
children hospitals in Tehran, Iran, from 2011 to 2018. The study
population included 120 patients presenting with seizure due to
neurometabolic disorders and 120 cases due to other causes. The types
of seizure and related clinical findings were assessed in both groups.
Results
There was a significant difference in the frequency of seizure types in
the two groups. Tonic and myoclonic seizures as well as infantile spasm
were observed more commonly in the patients with neurometabolic
disorders, while atonic, partial and generalized tonic-clonic seizures
were more common in the control group. In addition, frequency of
refractory seizure, age at onset of seizure, and pattern of involvement
in brain imaging were helpful for seizure differentiation.
Conclusion
The pattern of seizure and related findings varied in patients with
metabolic disorders, and was helpful for seizure differentiation. Thus,
these factors can contribute to early diagnosis and treatment.
Keywords :
Seizure , Children , Neurometabolic , Disorders
