Author/Authors :
Khabbaz, Bahareh Biomedical Engineering Department - Faculty of Engineering - Islamic Azad University Central Tehran Branch , Solouk, Atefeh Biomedical Engineering Department - Faculty of Engineering - Islamic Azad University Central Tehran Branch , Mirzadeh, Hamid Polymer Engineering and Color Technology Department - Amirkabir University of Technology (Tehran Polytechnic), Tehran
Abstract :
Soy protein isolate (SPI), due to its biocompatibility, biodegradability, abundance and being inexpensive, is a suitable polymer
for medical applications. In this study, electrospun nanofibrous mats (ENMs) and casting films (CFs), comprising polyvinyl
alcohol (PVA)/SPI, were prepared and compared. Both crosslinked ENMs and CFs physical, chemical, mechanical, and
biological properties were investigated for wound-healing applications. Considering the importance of exudate absorption by
wound dressing the uptake test of all samples was performed in simulated exudate solution. The amount of absorbed exudate,
water vapor transmission rate, and mechanical elongation for CFs were 69.243% ± 22.7, 266.7 g/m2 day, and 2.0825% and
increased to 383.33% ± 105.3, 1332.02 g/m2 day, and 12.292% in the case of ENMs, respectively. There was no significant
difference between cell supporting of the two samples due to similar composition and their non-toxic properties. The results
showed that ENMs have promising potential in wound-healing applications.
