Title of article :
Association of retinol binding protein 4 and insulin resistance: A review on molecular mechanisms
Author/Authors :
mohammadpour, zinat Department of Cellular and Molecular Nutrition - School of Nutritional Sciences and Dietetics - Tehran University of Medical Sciences, Tehran, Iran , Zabetian-Targhi, Fateme Department of Cellular and Molecular Nutrition - School of Nutritional Sciences and Dietetics - Tehran University of Medical Sciences, Tehran, Iran , mahmoudi, maryam Department of Cellular Molecular Nutrition - School of Nutritional Sciences and Dietetics - Tehran University of Medical Sciences, Tehran, Iran
Abstract :
Retinol (ROH) and its derivatives including vitamin A are substantial for several cells‟ functions. Retinol Binding Protein 4 (RBP4) is known as the career of vitamin A in blood. The main receptor for RBP4 is stimulated by retinoid acid gene 6 (STRA6). RBP4 circulates in bound with Transports Thyroxine and Retinol (TTR) to form ternary ROH-RBP-TTR complex. Recently, RBP4 implicated in insulin resistance which may exerts its functions through inflammatory pathways. Although studies indicated that RBP4 may have role in inflammation as an adipocytokine, the cellular and molecular mechanisms including the interaction between Holo- or Apo-RBP4 and their receptor to induce inflammation is controversial. In this review, we focus on molecular structure of RBP4, STRA6, and their interaction to induce inflammation and insulin resistance to illustrate the potential conflicts in this area.
Keywords :
Retinol binding protein 4 , RBP4 , Retinol , Insulin resistance , STRA6 , Inflammation , Transthyretin
