Author/Authors :
Abolhasan Choobdar, Farhad Department of Neonatology - Iran University of Medical Sciences, Tehran , Khalesi, Nasrin Department of Neonatology - Iran University of Medical Sciences, Tehran , Shojaee, Sorraya Department of Neonatology - Iran University of Medical Sciences, Tehran , Milani, Hani Department of Neonatology - Alborz University of Medical Sciences, Karaj , Behrouzi, Kamran Department of Neonatology - Alborz University of Medical Sciences, Karaj , Haghighi, Behzad Department of Pediatric Intensive Care - Iran University of Medical Sciences, Tehran , Manafi, Ali Department of Pediatric Intensive Care - Iran University of Medical Sciences, Tehran , Naderisorki, Mohammad Thalassemia Research Center - Mazandaran University of Medical Sciences, Sari
Abstract :
Background: ABO/Rh incompatibilities are common causes of hemolytic disease of newborn. Alloimmunization due to minor RBC antigens may also cause severe hemolysis and hyperbilirubinemia necessitating exchange transfusion in the early neonatal period.
Case Presentation: Here we report a rare case (first such report to our knowledge in Iran) of severe hemolytic disease of the newborn due to anti-Rh17 antibody (an antibody to the RhCc/Ee antigen protein) in a newborn with maternal blood group B Rh D--.
Conclusion: Presenting this case would improve the insight and knowledge about managing severe hemolytic anemia due to minor group alloantibodies postnatally, and highlight the importance of prenatal surveillance and diagnosis for the optimal management of alloimmune hemolytic disease.
Keywords :
Anti-Rh17 , Minor blood groups , Rh Isoimmunization , Hemolysis , Newborn , Hyperbilirubinemia
