Author/Authors :
asghari, rahim Hematology and Oncology Research Center - Tabriz University of Medical Sciences, Tabriz, Iran , esfahani, ali Hematology and Oncology Research Center - Tabriz University of Medical Sciences, Tabriz, Iran , asghari, mohammad Road Traffic Injury Research Center - Tabriz University of Medical Sciences and Department of Statistics and Epidemiology - Faculty of Health - Tabriz University of Medical Sciences, Tabriz, Iran , shab bidar, sakineh Department of Community Nutrition - School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran , bonyadi, morteza Center of Excellence for Biodiversity - Faculty of Natural Sciences - University of Tabriz, Tabriz, Iran , mohammadian, tahereh Center of Excellence for Biodiversity - Faculty of Natural Sciences - University of Tabriz, Tabriz, Iran , Ali-Moghaddam, kamran Center of Excellence for Biodiversity - Faculty of Natural Sciences - University of Tabriz, Tabriz, Iran
Abstract :
Objective: Vitamin D receptor (VDR) gene polymorphism has a role in susceptibility to risk of cancers. The aim of this study was to investigate the association of VDR gene polymorphisms with acute myeloid leukemia (AML).
Methods: In this case-control study, patients diagnosed with AML and healthy adult subjects were selected. Four single nucleotide gene polymorphisms of VDR gene (BsmI, TaqI, FokI, and ApaI) were determined using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and the odds of having AML was determined by unadjusted and adjusted logistic regression analysis.
Results: One hundred and thirty-three AML patients and 300 healthy people were included in the study. There were significant associations between the polymorphisms of FokI, and ApaI on the one hand and increased risk of AML (P= .021, and P<.001) on the other. The odds of the disease in patients with FF genotype were 2.5 times higher than patients with ff genotype and the odds of the disease in individuals with AA genotype was 5.6 times higher than the reference category of aa. In contrast, BsmI polymorphism had a protective effect, such that for those with BB and Bb genotypes there were 91% and 86% lower odds for getting AML than bb genotype, respectively (P<.001).
Conclusion: This study shows that there is a significant association between VDR gene polymorphisms and odds of getting AML. Further studies on different ethnic groups in populations with due consideration of environmental factors interacting with genotypes are highly recommended.
