Corneal Collagen Crosslinking for Treatment of Keratoconus

Purpose: The aim of this study was to assess the effects of corneal collagen cross-linking (CXL) on uncorrected visual acuity (UCVA), best corrected visual acuity (BCVA), subjective refraction, corneal irregularity, anterior chamber depth (ACD), corneal thickness, and k-readings. Patients and Methods: Eighty-four eyes of 44 patients with keratoconus were treated using corneal collagen cross-linking. UCVA, BCVA, and subjective refraction were evaluated pre-operatively as well as 3 months and 4 years after treatment and corneal Orbscan results were evaluated preoperatively and 4 years after treatment. Comparisons were made using paired sample t tests and a P values less than 0.05 were considered statistically significant. Results: There was a significant reduction in the mean thickness of the thinnest point of the cornea from 462.24 ± 46.95 µm preoperatively to 454.36 ± 55.32 µm (P < 0.05) at the last follow-up. The mean maximum and mean minimum curvature values reduced significantly from 48.00 ± 4.02 D and 45.03 ± 2.88 D preopera-tively to 47.56 ± 3.75 D (P < 0.05) and 44.64 ± 2.94 D (P < 0.001), respectively at the last follow-up. The UCVA (P = 0.309), BCVA (P = 0.594), subjective spherical equivalent (P = 0.591), subjective cylindrical refraction (P = 0.522), irregularity at the 3 mm (P = 0.338) and 5 mm (P = 0.915) zone of the cornea, anterior chamber depth (P = 0.072), and central corneal thickness (P = 0.203) remained unchanged. There were no significant postoperative complications.