Title of article :
Application of Green Chemistry in the Synthesis of Thiopyran Derivatives
Author/Authors :
Sheikholeslami-Farahani, Fatemeh Department of Chemistry - Firoozkooh Branch, Islamic Azad University, Firoozkooh
Abstract :
An efficient synthesis of 2H-thiopyran derivatives via three-component reaction of alkyl propiolate, benzoyl isothiocyanate or its derivatives and alkyl bromides in the presence of triphenylphosphine in water at 80o C without using any catalyst in water is described. The method offers several advantages including high yields of products and an easy work-up procedure.
Keywords :
Triphenyl Phosphite , Dialkyl Acetylenedicarboxilates , Multicomponent reactions , Triethyl phosphite
