Title of article :
One-Pot Multi-Component Synthesis of Dihydropyrimidinones via Biginelli Condensation
Author/Authors :
Sargordan Arani, Mohsen Department of Chemistry - Faculty of Science - Shahr-e-Rey Branch, Islamic Azad University, Tehran , Mirza, Behrooz Department of Chemistry - Karaj Branch, Islamic Azad University, karaj , Moghanlou, Mohammad Department of Chemistry - Faculty of Science - Shahr-e-Rey Branch, Islamic Azad University, Tehran
Abstract :
Three-component reactions have emerged as useful methods because the combinationof three components to generate new products in a single step is extremely economical,among the multi-component reactions. A green, simple, efficient, and cost-effective procedure has been carried out by the synthesis of dihydropyrimidinonesin Biginelli’s condensation of ethyl cyanoacetate, aldehyde and urea or thiourea .H3 BO3 , H2 C2 O4 , Me3 SiCl (TMSCl) using as catalyst and compared product yield.Products were characterized with IR, 1 H NMR, 13C NMR and mass spectroscopy
Keywords :
Biginelli reaction , Dihydropyrimidinones , one-pot synthesis , Ethyl cyanoacetate
