Title of article :
4-Sulfobenzoic Acid as an Efficient Catalyst for the Preparation of 3,4-dihydropyrimidin-2-(1H)-ones Under Solvent-free Conditions
Author/Authors :
Oudi, Ali Department of Chemistry - Faculty of Science - University of Sistan and Baluchestan, Zahedan , Hazeri, Nourallah Department of Chemistry - Faculty of Science - University of Sistan and Baluchestan, Zahedan , Fatahpour, Maryam Department of Chemistry - Faculty of Science - University of Sistan and Baluchestan, Zahedan
Abstract :
In this research, one-pot three-component synthesis of 3,4-dihydropyrimidin-2-(1H)-ones have been developed using Biginelli reaction from the interaction between ethyl/methyl acetoacetate, aromatic aldehydes, and urea/thiourea in the presence of 4-sulfobenzoic acid as a new, effective, inexpensive, and available bronsted acid. Avoidance of toxic and dangerous solvents, easy isolation of products without the need of column chromatography, high yields, and short reaction time are some important features of the present method.
Keywords :
3, 4-dihydropyrimidin-2-(1H)-one , 4-sulfobenzoic acid , One-pot , solvent-free
