Title of article :
The Chemoselective Fischer’s Synthesis of Indolenine Derivatives By iso-Butyric Acid As A Weak Organic Acid Catalyst
Author/Authors :
sajjadifar, sami Department of Chemistry - Payame Noor University , Amini, Z Department of Chemistry - Payame Noor University , Issa, Navabi Department of Chemistry - Payame Noor University , Jabbari, Hadi Department of Chemistry - Payame Noor University , Pouralimardan, Omidali Department of Chemistry - Payame Noor University
Abstract :
Iso-butyric acid as a new, simple, and expensive solvent/catalyst was successfully used for the chemoselective Fischer’s synthesis of indolenines derivatives 3a-r by one-pot condensation reaction of various phenylhydrazines 1a-e with the substituted acetophenones 2a-c at reflux conditions. In this protocol, all products 3a-r were obtained in high yields and short reaction time. The structures of the product were established with spectroscopic data of 1H NMR, 13C-NMR, and FT-IR.
Keywords :
Fischer’s synthesis , Indolenines , 3H-Indole , Phenylhydrazine , Iso-butyric acid
