A Sensitive Modified Electrode based on Reduced Graphene Oxide Composite with Cu@SnS/SnO2 for Determination of Benserazide

Benserazide (BZ), a dopadecarboxylase inhibitor, is the most widely prescribed drug in treatment of Parkinson’s disease. Therefore, it is urgent to develop a sensitive and selective BZ sensor. We used tin oxide nanocomposite (Cu@SnS/SnO2) for developing a new electrochemical sensor for determination of BZ in human urine and pharmaceutical tablets. Morphology of the synthesized Cu@SnS/SnO2 was investigated by scanning electron microscopy (SEM). The modified electrode was characterized by electrochemical impedance spectroscopy (EIS) and voltammetric techniques. The sensitivity and limit of detection of RGO/Cu@SnS/SnO2 electrode for BZ are 0.275 µAµM−1 in the range of 1-100 µM and 0.58 µM. Moreover, the proposed electrode shows good selectivity, reproducibility and stability. The applicability of the modified electrode was demonstrated by determination of BZ in human urine and pharmaceutical formulation.