Electrochemical Determination of Sulfapyridine using a New Approach of Modified Electrode based on Amplification with Room Temperature Ionic Liquid and ZnO Nanoparticle

An electroanalytical sensor amplified with ZnO nanoparticle (ZnO NPs) and 1butyl-2,3-dimethylimidazolium hexafluorophosphate (1B23DIPF6) was fabricated as new analytical approach for determination of sulfapyridine in different real samples. The ZnO NPs was synthesized by a simple precipitation method with low calcination temperature (⁓ 300 °C) and characterized by XRD and FESEM methods and results confirm a particle size ⁓45.2 nm for ZnO NPs. In addition, the two-fold amplification of paste electrode (PE) with ZnO NPs and 1B23DIBr (PE-ZnO NPs-1B23DIPF6) created a new tool for determination of sulfapyridine in the concentration range of 0.09-400 µM with detection limit 30.1 nM. On the other hand, the PE-ZnO NPs-1B23DIPF6 showed recovery data between 99.4%-104.1% for determination of sulfapyridine in some different real samples such as urine and tablet.