Title of article :
Four-component Cascade Reaction was Programmed and Catalyzed by B(OH)3.H2O as an Efficient and Green Catalytic System
Author/Authors :
Moosavi-Zare, Ahmad Reza Sayyed Jamaleddin Asadabadi University , Afshar-Hezarkhani, Hadis Sayyed Jamaleddin Asadabadi University , Khakizadeh, Vahid Faculty of Science - Department of Chemistry - K. N. Toosi University of Technology , Goudarziafshar, Hamid Sayyed Jamaleddin Asadabadi University
Abstract :
An aqueous solution of boric acid, as an efficient and green catalytic system, was efficiently utilized four-component cascade reaction of aryl aldehydes, dimedone, β-ketoesters and ammonium acetate to give hexahydroquinolines. By the reaction of boric acid with water, H+ was generated and efficiently catalyzed the reaction under mild and green condition. Also, optimization of the reaction condition was investigated using the response surface method {Central Composite Design (CCD)}.
Keywords :
Boric acid , Hexahydroquinoline , Cascade reaction , Aqueous solution
