Title of article :
Synthesis of Poly-substituted Hydroquinolines Employing Lactic Acid as a Robust Catalyst through the Diastereoselective, One-pot Eight-component Reaction
Author/Authors :
Noori Sadeh, Fatemeh Department of Chemistry - Faculty of Sciences - University of Sistan and Baluchestan , Lashkari, Mojtaba Faculty of Sciences - Velayat University , Hazeri, Nourallah Department of Chemistry - Faculty of Sciences - University of Sistan and Baluchestan , Fatahpour, Maryam Department of Chemistry - Faculty of Sciences - University of Sistan and Baluchestan , Maghsoodlou, Malek Taher Department of Chemistry - Faculty of Sciences - University of Sistan and Baluchestan
Abstract :
With the aim of developing an efficient and eco-friendly method for a diastereoselective synthesis of dispiro[tetrahydroquinoline-bis(2,2-dimethyl[1,3] dioxane-4,6-dione)] derivatives, a one-pot pseudo-eight-components reaction between arylamines, aromatic aldehydes and Meldrum’s acid has occurred in the presence of lactic acid as catalyst. The salient aspects of this protocol are, operational simplicity, facile product separation, a cheap and eco-friendly catalyst, clean reaction conditions, absence of any hazardous organic solvent and moderate to high yields.
Keywords :
Diastereoselective , Dispiro[tetrahydroquinoline-bis(2 2-dimethyl[1 3] dioxane-4 6-dione)] , Pseudo-eight-components reaction , Meldrum’s acid Lactic acid
