Title of article :
Synthesis of Some Nitrogen Functional Derivatives of 5-substituted-6-azauracil as Biologically Active Compounds
Author/Authors :
Kabirifard, Hassan Department of Chemistry - North Tehran Branch, Islamic Azad University, Tehran , Alimardani, Zeinab Department of Chemistry - North Tehran Branch, Islamic Azad University, Tehran , Ataeimehr, Natasha Department of Chemistry - North Tehran Branch, Islamic Azad University, Tehran , Rezai, Gisa Department of Chemistry - North Tehran Branch, Islamic Azad University, Tehran
Abstract :
3-Arylhydrazono-2,4-dioxo-4-phenylbutanoates have been prepared by the coupling of benzoylpyruvate with aryldiazonium chlorides. Reactions of the 3-arylhydrazono-2,4- dioxo-4-phenylbutanoates with 1-aminoguanidine, semicarbazide, and thiosemicarbazide gave 5-substituted 2-imino-6-azauracil (3a), 6-azauracil (3b), and 2-thio-6-azauracil (3c), respectively. The analytical data of these compounds - IR, 1 H, and 13C NMR spectral data - are reported.
Keywords :
Coupling , Benzoylpyruvate , Arylhydrazone , 1, 2, 4-Triazin-5-one , 6-Azauracil
