Author/Authors :
Hemmati, Aliasghar Department of Pharmacology Toxicology, School of Pharmacy - Physiology Research Center - Jundishapur University of Medical Sciences, Ahvaz, Iran , Namjuyan, Forough Department of Pharmacognosy - School of Pharmacy - Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran , Yousefi, Sadegh Department of Pharmacology - School of Pharmacy - Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran , Houshmand, Gholamreza Department of Pharmacology - School of Medicine - Mazandaran University of Medical Sciences, Sari, Iran , Khadem Haghighian, Hossein Department of Nutrition - Faculty of Health - Qazvin University of Medical Sciences, Qazvin, Iran , Rezaei, Anahita Department of Pathology - Faculty of Veterinary Medicine - Shahid Chamran University, Ahvaz, Iran
Abstract :
BACKGROUND Wound healing is the process of repair following an injury to the skin and other soft tissues. In this study, the effect of n-hexane d-chloromethane extract (1: 1) of root Onosma bulbotrichum DC on the second degree burn in rabbit model was investigated. METHODS Thirty-six adult rabbits of both sexes were randomly divided into six groups, control (without treatment), negative control (treatment with cold cream), positive control (treatment with silver sulfadiazine), and treatment groups with 5%, 1% and 2% O. bulbotrichum cream and assessed histologically. RESULTS The best result was shown in 5% O. bulbotrichum group similar to silver sulfadiazine group. The maximum amount of collagen and the tensile strength of tissue were observed in 5% O. bulbotrichum and silver sulfadiazine groups. Histopathological examination showed that burn healing in treatment group with 5% O. bulbotrichum was faster than other groups. CONCLUSION The 5% O. bulbotrichum cream was shown to have healing, and anti-inflammatory effects when used in treatment of second degree burns.
Keywords :
Burn , Healing , Silver sulfadiazine , Onosma bulbotrichum , Rabbit
