Title of article :
INTERLEUKIN 10, LIPID PROFILE, VITAMIN D, SELENIUM, METABOLIC SYNDROME, and SERUM ANTIOXIDANT CAPACITY IN ELDERLY PEOPLE WITH and WITHOUT CARDIOVASCULAR DISEASE: AMIRKOLA HEALTH and AGEING PROJECT COHORT-BASED STUDY
Author/Authors :
Nematollahi, Hamid Reza Department of Biochemistry - School of Sciences - Payame Noor University of Mashhad , Hosseini, Reza Department of Community Medicine - Babol University of Medical Sciences , Bijani, Ali Health Research Institute - Babol University of Medical Sciences , Akhavan-Niaki, Haleh Health Research Institute - Babol University of Medical Sciences , Parsian, Hadi Department of Biochemistry - School of Sciences - Babol University of Medical Sciences , Pouramir, Mahdi Department of Cardiology - School of Medicine - Babol University of Medical Sciences , Saravi, Mehrdad Department of Immunology - School of Medicine - Babol University of Medical Sciences , Bagherzadeh, Mojgan Department of Biochemistry - School of Medicine - Babol University of Medical Sciences , Mosapour, Abbas Department of Biochemistry - School of Sciences, Payame Noor University of Mashhad , Saleh-Moghaddam, Massud Department of Biochemistry - School of Sciences, Payame Noor University of Mashhad , Rajabian, Majid Department of Biochemistry - School of Sciences, Payame Noor University of Mashhad , Golpour, Monireh Student Research Committee - School of Medicine - Mazandaran University of Medical Sciences , Mostafazadeh, Amrollah Health Research Institute - Babol University of Medical Science
Abstract :
BACKGROUND: The age-related autoinflammation-mediated atherosclerosis is associated with some immunological, nutritional, and metabolic parameters and redox status. Here, we evaluated the association of circulatory interleukin 10 (IL-10) levels with lipid profile, some nutrients, and total anti-oxidant capacity in elderly people who presented cardiovascular disease (CVD) with or without metabolic syndrome (MetS) and in healthy subjects.
METHODS: In this cross-sectional case-control study, 258 sera prepared from elderly people (144 healthy and 114 patient subjects) who participated in a community-based study, the Amirkola Health and Ageing Project (AHAP), were analyzed for IL-10, lipid profile, vitamin D, selenium (Se), antioxidant capacity, and MetS.
RESULTS: Compared to patients, the healthy subjects exhibited higher levels of circulatory IL-10 among individuals with detectable serum IL-10 (P = 0.036). However, this difference was not observed when total subjects from both groups were compared, since more than 90% of those people were IL-10-negative. Se, vitamin D, and antioxidant levels were similar in both groups. There was a negative association between IL-10 and body mass index (BMI) (P < 0.050) and an equivocal association with vitamin D levels, whereas the association between IL-10 and other indicated variables was not significant. Significant association was observed between MetS and CVD prevalence (P < 0.001). There was a positive correlation between Se and total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglyceride (TG) (P < 0.010) in healthy subjects and with TC in patients (P < 0.050).
CONCLUSION: A major proportion of elderly people were serum IL-10-negative, whereas independently to IL-10, MetS was most common in patients with CVD. Weight loss may have the potential to increase IL-10 levels in the elderly.
Keywords :
Interleukin 10 , Lipids , Cardiovascular Diseases , Antioxidants , Metabolic Syndrome , Elderly
Journal title :
Arya Atherosclerosis
