Author/Authors :
Aryanian, Zeinab Autoimmune Bullous Diseases Research Center - Tehran University of Medical Sciences, Tehran, Iran , Shahabandaz, Hosein Department of Radiology and Radiotherapy - School of Medicine - Babol University of Medical Sciences, Babol, Iran , Abdollahzadeh Sangrody, Meysam Student Research Committee - Babol University of Medical Sciences, Babol, Iran , Shirzadian, Azar Department of Dermatology - School of Medicine - Babol University of Medical Sciences, Babol, Iran , Tirgartabari, Soodabeh Clinical Research Development Center - Shahid Yahyanezhad Hospital - Babol University of Medical Sciences, Babol, Iran , Bijani, Ali Department of Statistic and Epidemiology - School of Medicine - Babol University of Medical Sciences, Babol, Iran , Fahim, Shabnam Department of Dermatology - Razi Hospital - Tehran University of Medical Sciences, Tehran, Iran , Etesami, Ifa Department of Dermatology - Razi Hospital - Tehran University of Medical Sciences, Tehran, Iran , Azizpour, Arghavan Autoimmune Bullous Diseases Research Center - Tehran University of Medical Sciences, Tehran, Iran , Goodarzi, Azadeh Department of Dermatology - School of Medicine - Rasoul Akram Hospital - Iran University of Medical Sciences, Tehran, Iran
Abstract :
Background: Lichen planus is a chronic inflammatory disease
associated with an increased risk of subclinical atherosclerosis
and cardiovascular diseases. This study aimed to evaluate patients
with lichen planus using carotid Doppler ultrasound parameters.
Methods: Forty patients with lichen planus and 40 controls were
included in this study. Common carotid artery intima-media
thickness (CIMT) and the number of atherosclerotic plaque were
measured and compared to the control group. Total cholesterol,
triglyceride, low-density lipoprotein (LDL) and high-density
lipoprotein (HDL) levels were measured. Leptin level (Pg/ml)
was measured using the enzyme-linked immunosorbent assay
(ELISA) method (Leptin ELISA kit, Orgenium, Finland).
Results: Significant difference was found between the groups
in terms of CIMT (P=0.005). The median range for blood leptin
level, triglyceride, cholesterol, and LDL was higher for lichen
planus patients than for controls. We found a significant
difference between the severity of LP and CIMT (P=0.035). No
statistical difference was found between LP and the number of
atherosclerotic plaque.
Conclusions: Our study suggested that measurement of the
mean intima media wall thickness of the common carotid artery
could be beneficial as a valuable.
