Prognosis of acute kidney injury based on pRIFLE criteria among patients admitted to pediatric intensive care unit in Northern Iran; a single center study

Introduction: Acute kidney injury (AKI) is a frequent problem in pediatric intensive care units, while it is associated with significant mortality. Objectives: The aim of this study was to determine the prevalence and prognosis of AKI based on pRIFLE (pediatric risk, injury, failure, loss, end-stage renal disease) criteria among children admitted to a pediatric intensive care unit Patients and Methods: This research included 323 children from 1 month to 14 years old age, admitted to the pediatric intensive care unit. The pRIFLE was determined in patients along with urinary output and creatinine level. The pediatric risk of mortality (PRISM) score was also assessed. Results: Mean PRISM III score was 34.66 ± 15.97 and 17.72 ± 6.06 respectively in children with and without AKI (P = 0.001). It was found that variables of encephalopathy, PRISMIII score and gender were the only variables affecting the incidence of AKI. Conclusion: While pRIFLE criteria are appropriate and efficient criteria for early diagnosis of AKI, their role alone as prognostic factors of mortality require further studies.