Title of article :
Apolipoprotein L1 associated nephropathy; an overview
Author/Authors :
Akhavan Sepahi, Mohsen Department of Pediatric Nephrology - School of Medicine and Pediatric Clinical Research of Development Center - Qom University of Medical Sciences , Bhaskar, LVKS Sickle Cell Institute Chhattisgarh - Raipur (CG), India , Tolouian , Audrey The University of Texas at El Paso - School of Nursing, USA , Tolouian, Ramin Division of Nephrology - College of Medicine - University of Arizona, USA
Abstract :
Genetic variants of apolipoprotein L1 (APOL1) have been recognized as a risk factor for kidney disease in people of African ancestry. APOL1 mediate renal damage in podocytes through necrosis, apoptosis and pyroptosis processes. APOL1 gene contains G1 and G2 alleles that mediate in increasing risk of renal disorders in African Americans. People who carry APOL1 risk alleles have a three to four-fold increase risk for non-diabetic renal disease (NDRD), Idiopathic focal segmental glomerulosclerosis (FSGS) and HIV-associated nephropathy (HIVAN). Therefore, identifying genetic factors involved in the pathogenesis of renal disorders, including APOL1 risk variants, may help to improve our understanding of kidney problems
Keywords :
Apolipoprotein L1 , Chronic kidney disease , End-stage renal disease , Focal segmental glomerulosclerosis , HIV-associated nephropathy , APOL1-related nephropathy , Podocye
Journal title :
Journal of Renal Injury Prevention
