Title of article
Effects of saffron on homocysteine, and antioxidant and inflammatory biomarkers levels in patients with type 2 diabetes mellitus: a randomized double-blind clinical trial
Author/Authors
Shahbazian, Hajieh Diabetes Research Center - Health Research Institute - Ahvaz Jundishapur University of Medical Sciences , Moravej Aleali, Armaghan Diabetes Research Center - Health Research Institute - Ahvaz Jundishapur University of Medical Sciences , Amani, Reza Department of Clinical Nutrition - School of Nutrition & Food Science - Food security Research Center - Isfahan University of Medical Sciences , Namjooyan, Foroogh Department of Pharmacognosy - School of Pharmacy - Ahvaz Jundishapur University of Medical Sciences , Cheraghian, Bahman Department of Epidemiology & Biostatistics - School of Public Health - Ahvaz Jundishapur University of Medical Sciences , Latifi, Mhmoud Diabetes Research Center - Health Research Institute - Ahvaz Jundishapur University of Medical Sciences , Bahrainian, Sara Aerosol Research Laboratory - Department of Pharmaceutics - School of Pharmacy - Tehran University of Medical Sciences , Ghadiri, Ataallah Cellular and molecular research center - Department of Immunology - School of Medicine - Ahvaz Jundishapur University of Medical Sciences
Pages
10
From page
436
To page
445
Abstract
Objective: Type 2 diabetes mellitus (T2DM) is one of the most common health problems worldwide. Studies have shown that saffron and its derivatives may have therapeutic potentials in T2DM through reducing plasma glucose. The present study aimed to evaluate the effects of saffron extract on serum anti-inflammatory and antioxidant variables in T2DM patients.
Materials and Methods: This was a double-blind randomized clinical trial conducted on 64 T2DM patients. Participants received either 15 mg of saffron or placebo capsules (two pills per day) for 3 months Anthropometric indices, homocysteine, serum anti-inflammatory and antioxidant variables and dietary intake were assessed pre- and post-intervention.
Results: After 3 months of treatment, interleukin-6 (IL-6), and tumor necrosis factor (TNF-α) increased significantly in both group (p<0.05). No significant differences were observed for total antioxidant capacity (TAC), malondialdehyde (MDA),highsensitivity C-reactive protein (hs-CRP) and interleukin 10(IL-10) after the treatment period (p>0.05). Homocysteine decteased significantly in control group (p<0.05).
Conclusion: Our results showed no improvement in homocystein levels, antioxidant status and inflammatory biomarkers in T2DM patients after treatment with saffron.
Keywords
Inflammatory , Antioxidant , Saffron , Type 2 Diabetes Mellitus , Biomarkers
Journal title
Avicenna Journal of Phytomedicine AJP)
Serial Year
2019
Record number
2499672
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