Oxidative Stress Balance as a diagnostic marker in Stroke

Background and objectives: Ischemic stroke (IS) is a debilitating disorder with no reliable prognostic or diagnostic biomarker. Here, we evaluated the serum level of Oxidative Stress Balance and assessed their diagnostic and prognostic value for IS. Methods: Sera from 52 patients with IS and 52 age- and sex-matched healthy subjects were collected. All patients were subjected to sample collection at the time of admission, 24 and 48 hours later, at the time of discharge and three months later .Oxidative Stress Balance expression was assessed by ELISA. Statistical measures for diagnostic accuracy of quantitative measures were conducted. Results: We demonstrated Oxidative Stress Balance was elevated at the time of admission in comparison to normal subjects. ROC curve analyse revealed that Oxidative Stress Balance (AUC = 0.7337; P<0.0001) was acceptable diagnostic value to discriminate IS patients from normal subjects. Kaplan-Meier survival analyse shown that Oxidative Stress Balance(P=0.8584) had no prognostic value. Conclusion: Oxidative Stress Balance could be introduced as suggested biomarker to segregate IS patients from normal subjects.