Title of article :
Dietary restriction prevents dendritic changes of pyramidal neurons in hippocampal and prefrontal cortex in diabetic rat
Author/Authors :
Torabi, Taher School of Medicine - Shahed University, Tehran, Iran , Azizzadeh Delshad, Alireza Department of Anatomy - School of Medicine - Shahed University, Tehran, Iran. , Roghani, Mehrdad Neurophysiology Research Center - Shahed University, Tehran, Iran
Pages :
5
From page :
28
To page :
32
Abstract :
Background and Objective: Diabetes mellitus (DM) is a common endocrine disorder with cognition decline. Dietary restriction (DR), also known as calorie restriction (CR), and reduction of foodstuff intake in rodents result in increased lifespan with protective potential. The aim of this study was to analyze the effect of DR on dendritic spine loss in streptozotocin (STZ) diabetic rats. Materials and Methods: Rats were grouped into control, diabetic, and diabetic with DR. For induction of diabetes, STZ (i.p.) at a dose of 60 mg/kg was used. DR was applied from one month before till 2 months after diabetes induction. Finally, dendritic changes of pyramidal neurons in hippocampal and prefrontal cortex were assessed using Golgi impregnation method. Results: Our histochemical findings showed a significant reduction of dendritic mushroom spines of pyramidal neurons of hippocampal CA1 and prefrontal areas in the diabetic rats that was significantly attenuated in the presence of DR. Conclusion: DR application could appropriately prevent dendritic spine loss and in this way may have a beneficial effect on cognitive abilities in diabetic condition.
Keywords :
Dendritic spines , Dietary restriction , Streptozotocin , Diabetes mellitus
Journal title :
Journal of Basic and Clinical Pathophysiology
Serial Year :
2019
Record number :
2499996
Link To Document :
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