Title of article :
A Genetic Association Study of MTHFR C677T Polymorphism with Risk of Metabolic Syndrome: A Systematic Review and Meta-Analysis
Author/Authors :
Azizi, Soheil Department of Laboratory Sciences - Mazandaran University of Medical Sciences , Shamshirian, Amir Student Research Committee - Mazandaran University of Medical Sciences , Alizadeh-Navaei, Reza Gastrointestinal Cancer Research Center - Mazandaran University of Medical Sciences , Jafarpour, Hamed Student Research Committee - Mazandaran University of Medical Sciences , Asemi, Zatollah Nutrition in Metabolic Diseases - Kashan University of Medical Sciences , Tamtaji, Omid Reza Physiology Research Center - Kashan University of Medical Sciences , Vaziri, Mohammad Sadegh Student Research Committee - Hormozgan University of Medical Sciences , Homayounfar, Reza Non-Communicable Disease Research Center - Fasa University of Medical Sciences , Rezaei Shahmirzadi, Arash Student Research Committee - Golestan University of Medical Sciences , Alipoor, Reza Nutrition in Metabolic Diseases - Kashan University of Medical Sciences
Abstract :
Methylenetetrahydrofolate reductase (MTHFR) is an enzyme that plays a crucial role as a methyl-group donor in demethylation of homocysteine. The aim of this systematic review and meta-analysis was to study the relationship between MTHFR gene polymorphism and metabolic
syndrome (MS). We used search engines and databases such as Science Direct, Google Scholar,
Embase, Cochrane Library, and PubMed to identify eligible studies up to 2018. The articles
were studied based on keywords including MTHFR, mutation, variant, and polymorphism in
combination with MS. Data was analyzed using Comprehensive Meta-Analysis version 2.2.064
software. After extracting the data from seven articles, the total number of subjects was 1280
in the patient group and 1374 in the control group. The odds ratio was estimated to be 1.078
for the allele model of T vs. C (95% confidence interval [CI]: 1.626-0.715), 1.157 for the allele model of CC vs. CT (95% CI: 0.829-1.615), 1.020 for the allele model of CT + TT vs.
CC (95% CI: 1.611-0.646) and 0.799 for the allele model of TT vs. CC + CT (95% CI: 1.185-
0.539). As well, the results showed no statistically significant correlation between polymorphism genotypes of the MTHFR gene and MS (P<0.05). In general, this study showed that the
presence of C677T polymorphism in the MTHFR gene has no effect on the incidence of MS.
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Keywords :
MTHFR , Metabolic Syndrome , Polymorphism , Variant , Meta-Analysis , Methylenetetrahydrofolate Reductase
Journal title :
Galen Medical Journal (GMJ)
